Endocrine Abstracts

Parathyroid cancer is a rare cause of primary hyperparathyroidism (PPH). The objective of this work is to discuss clinical and therapeutic specificities of these tumors.Case n°151-year-old woman from a consanguineous marriage, with a family history of recurrent renal lithiasis, neoplasia, and a personal history of breast neoplasia and uterine fibroid, consulted for abdominal pain, vomiting and weight loss. The diagnosis of pri...

Background: Beckwith–Wiedemann syndrome (BWS) is an imprinting disorder characterized by overgrowth, tumor predisposition, and congenital malformation(s). Diabetes mellitus is not characteristic of BWS. If anything, BWS is associated with hypoglycaemia which is believed to be related to hyperinsulinaemia due to an unknown mechanism. The presentation of concurrent BWS and permanent diabetes mellitus (DM) is uncommun.Case Report: We report the case of...

Introduction: Papillary thyroid microcarcinomas (PTMC) usually manifest a slow progression, commonly displaying local-regional extension, contributing to a generally favorable prognosis. However, certain instances are complicated by lymph node metastasis, a pivotal factor influencing therapeutic strategies. The aim of this study was to evaluate the epidemiological, clinical, and histological characteristics of patients with PMCT and lymph node metastasis.<p class="abstext"...

Introduction: Inflammation has been involved in the physiopathology of diabetic ketoacidosis (DKA). Hematological inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and white blood cell count (WBC) can serve as predictive markers for a systemic inflammatory response. This study aimed to evaluate hematological inflammatory markers in T1DM patients with DKA and without-DKA in an uninfected state and to determine their role in the prediction of DKA.<p class="ab...

Introduction: Mitochondrial neuro-gastro-intestinal encephalopathy (MNGIE) is a rare autosomal recessive disease caused by a mutation in the TYMP gene.Patients-methods: Retrospective study including 2 cases (brother and sister) followed for MNGIE confirmed by genetic study at the endocrinology department of Sfax.Results: -> 1st case: 25-year-old man, follow-up for diabetes, dilated cardiomyopathy, renal lithiasis, MNGIE.<p ...

Introduction: Masked hypertension (MH) is a relatively recent description leading to a similar cardiovascular risk as permanent hypertension. Masked hypertension is more common among diabetic patients.Methods: This was a case-control study. We performed 24-hour ambulatory BP in 53 type 2 diabetic patients normotensive in clinical measurement. We compared both Masked Hypertension and Normotensive groups according to clinical/laboratory parameters and targ...

Autoimmune thyroid disease (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), is caused by multiple genetic and environmental factors. The clinical and immunological features of GD and HT are distinct; however, there are multiplex families with both GD and HT. In order to study the genetic susceptibility factors to AITDs, we have followed up 115 control members belonging to a large Tunisian family with a high prevalence of AITDs (Akr family) dur...

The metabolic syndrome (MetS) is a constellation of physiological and biochemical abnormalities characterized by obesity, hyperglycaemia, elevated triglycerides and decreases in high density lipoprotein cholesterol (HDL-C), and hypertension. The MetS promotes atherosclerosis, and increases the risk of developing diabetes and cardiovascular disease (CVD), as well as rates of mortality. Thus, it has become one of the major public health challenges worldwide. In Tunisia, few stud...

Introduction: Pituitary apoplexy (PA) is a rare incident defined by the occurrence of necrosis and/or haemorrhage of the pituitary gland. PA is a clinical syndrome characterized by the sudden onset of headache, vomiting, visual impairment and decreased consciousness in some cases. The objectives of our study are to describe its clinical, biological and imaging features as well as the management of PA in the region of Sfax.Patients and methods: It is a re...

Introduction: Hyperthyroidism (HT) has been associated with hepatic dysfunction in the presence or absence of congestive heart failure (CHF). Our objective is to study the correlation between the clinical and biological presentation of hepatic abnormalities and the cardiac status.Patients and methods: This retrospective study included 17 patients hospitalized in the endocrinology department of Hedi Chaker Hospital in Sfax over 20 years (1997–2017). ...